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. 2021 Jul 30;71(10):2030–2042. doi: 10.1136/gutjnl-2020-322874

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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ΔNp63 maintains a basal cell differentiation state while repressing duct cell identity. (A) Volcano plot and (B) KEGG pathway analysis of differentially expressed genes after KD of ΔNp63⁺ in HPDE cells (n=3, p<0.01 and FDR<0.01). In orange, the pathways represented by downregulated genes, in purple those from the upregulated genes. (C) Volcano plot of basal and (D) of ductal markers in the same RNAseq data. (E) Confirmation of basal (P63 and KRT5) and classical ductal marker KRT19 by immunofluorescence staining and (F) quantitative RT-PCR (*p<0.05; **p<0.01; ***p<0.001; ****p<0.0001). (G) Correlation of PAMG scores in ΔNp63 KD (purple) and control (orange) HPDE samples (R =–0,95, p=0.0032). FDR, false discovery rate; KD, knockdown; PAMG, Pancreatic Adenocarcinoma Molecular Gradient.