Skip to main content
. 2022 Jul 4;81(10):1400–1408. doi: 10.1136/annrheumdis-2022-222229

Figure 2.

Figure 2

Psoriatic-arthritic-like (PsA) phenotype in mice with severe psoriasis-like disease. (A) Prevalence of psoriatic arthritis (PsA) in mice with inducible dual epidermal deletion of c-Jun and junB (DKO*) and triple epidermal deletion of c-Jun, JunB and S100A9 (TKO*) with severe psoriasis-like disease (n=20 per group). (B) Toluidine blue staining of the distal interphalangeal (DIP) joint of control wild-type (WT), DKO* and TKO* mice with PsA (scale bar=200 µm). (C) Quantification of toluidine blue staining intensity of articular cartilage in WT, DKO* and TKO* mice (WT n=4; DKO* n=8; TKO* n=6; each point represents the median of several joints measured per sample). (D) H&E-stained histological images showing psoriatic nail involvement with changes in the nail plate (P), nail matrix (M) and nail bed (B) of DKO* and TKO* mice and quantification of nail lesions (scale bar=100 µm). (E) H&E histological images of the distal phalanx (DP) showing enthesitis with high immune infiltration in the areas around the bone (scale bar=100 µm). (F) H&E histological images showing osteitis of the bone marrow (BM) of the distal phalanx (DP) in DKO* and TKO* mice (BM=bone marrow) with quantification of per cent area of bone marrow covered by inflammation (scale bar=100 µm).