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. 2022 Jul 4;81(10):1400–1408. doi: 10.1136/annrheumdis-2022-222229

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Proteomic analyses in whole ear extracts of DKO* and TKO* mice. (A) Volcano plot showing upregulated (red) and downregulated (blue) proteins (n=3–5 per condition; p<0.05); proteins in grey are below statistical significance. (B) Venn diagram depicting statistically significant upregulated proteins in (I) mice with inducible dual epidermal deletion of c-Jun and junB (DKO*) compared towild-type (WT) controls, (II) mice with triple epidermal deletion of c-Jun, JunB and S100A9 (TKO*) compared toWT mice and (III) TKO* compared to DKO* mice (n=3–5 per condition; p<0.05). (C) Heat map of significantly upregulated proteins (left) and Alluvial plot (right) of enriched biological processes associated to each protein.