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. Author manuscript; available in PMC: 2023 Aug 24.
Published in final edited form as: Expert Opin Drug Metab Toxicol. 2022 Aug 24;18(7-8):469–481. doi: 10.1080/17425255.2022.2113379

Figure 5. Plasma concentration of parent drug and its metabolite over time.

Figure 5.

Toxicity thresholds are shown for both parent compound (red dashed line) and metabolite (violet dashed line). Panel A represents the desired therapeutic condition in which the plasma concentration of parent drug as well as its metabolite(s) (blue line) remain below their respective toxicity thresholds. Panel B represents the condition in which the concentration of the metabolite exceeds its toxicity threshold, in this case due to induction of CYP during maintenance therapy, prompting an adverse reaction.