Table 2.

Function of target protein on tumor MDSCs.

Tumor	Target	Function	Ref
RCC NSCLC MOC2 HNSCC Neuroblastoma Melanoma	IL-1β/PD-1 Gr-1/ATRA CXCR2 CXCR1/2 NKG2D LXR/Apoe	To reduce the PMN-MDSCs To block G-MDSC To regulate NK cell function To modulate immune activity To improve the ability of T cells To change the number of MDSCs	(56) (57) (50, 51) (59) (60) (61)

RCC, Renal cell Carcinoma; NSCLC, Non-small cell lung cancer; MOC2, Oral cancer model; HNSCC, Head neck Squamous Cell Carcinoma.