Table 1.

Circulating miRNAs Serve as Potential Diagnostic Biomarkers for HCC

miRNAs	Source	Cohort Size	Ethnic Population	Detection Method of ncRNAs	AUC	Sensitivity (%)	Specificity (%)	Reference
miR-107	Serum	115 HCC vs 40 HC	Chinese	Microarray	0.730			[33]
miR-122	Plasma	40 HCC vs 20 HC	Egyptian	qRT-PCR	0.96	87.5	95	[35]
miR-122+AFP	Plasma	40 HCC vs 40 CHC	Egyptian	qRT-PCR	1	97.5	100	[35]
miR-199a	Serum	23 HCC vs.17 CH	Egyptian	qRT-PCR	0.856	54.5	100	[36]
miR-21	Plasma	126 HCC vs 30 CH	Japanese	qRT-PCR	0.773	61.1	83.3	[29]
miR-21	Plasma	126 HCC vs 50 HC	Japanese	qRT-PCR	0.953	87.3	92.0	[29]
miR-21	Serum	23 HCC vs.17 CH	Egyptian	qRT-PCR	0.943	100.0	81.2	[36]
miR-21+AFP	Plasma	126 HCC vs 30 CH	Japanese	qRT-PCR	0.823	81.0	76.7	[29]
miR-21+AFP	Plasma	126 HCC vs 50 HC	Japanese	qRT-PCR	0.971	92.9	90	[29]
miR-224	Plasma	40 HCC vs 20 HC	Egyptian	qRT-PCR	0.94	92.5	90	[35]
miR-224	Plasma	40 HCC vs 40 CHC	Egyptian	qRT-PCR	0.93	87.5	97	[35]
miR-224+AFP	Plasma	40 HCC vs 40 CHC	Egyptian	qRT-PCR	0.93	90	100	[35]
miR-3126-5p	Serum	115 HCC vs 40 HC	Chinese	Microarray	0.881			[33]
miR-34a	Serum exosome	60 HCC vs 60 HC	Chinese	qRT-PCR	0.664	78.3	51.7	[37]
miR-34a+AFP	Serum exosome	60 HCC vs 60 HC	Chinese	qRT-PCR	0.855	68.3	93.3	[37]
miR-424	Serum	123 HCC vs 76 HC	Chinese	qRT-PCR	0.768	75.0	72.4	[38]
miR-665	Serum	80 HCC vs 80 LC	Egyptian	qRT-PCR	0.930	92.5	86.3	[39]
miR-9-3p	Serum	35 HCC vs 33 HCV	Egyptian	qRT-PCR		91.43	87.88	[30]
miR-9-3p	Serum	35 HCC vs 32 HC	Egyptian	qRT-PCR		91.43	87.50	[30]
miR-92a-3p	Serum	115 HCC vs 40 HC	Chinese	Microarray	0.705			[33]
miR-122 + miR-192 + miR-21 + miR-223 + miR-26a + miR-27a + miR-801	Plasma	204 HCC vs 60 LC + 75 CHB + 68 HC	Chinese	Microarray and qRT-PCR	0.864	68.6	90.1	[32]
miR-122 + miR-192 + miR-21 + miR-223 + miR-26a + miR-27a + miR-801	Plasma	196 HCC vs 56 LC + 72 CHB + 66 HC	Chinese	Microarray and qRT-PCR	0.888	81.8	83.5	[32]
miR-29a + miR-29c + miR-133a + miR143 + miR-145 + miR-192 + miR-505	Serum	108 HCC vs 47 LC + 51 CHB + 51 HC	Chinese	qRT-PCR	0.826	80.6	84.6	[34]
miR-29a + miR-29c + miR-133a + miR143 + miR-145 + miR-192 + miR-505	Serum	153 HCC vs 71 LC + 68 CHB + 60 HC	Chinese	qRT-PCR	0.817	74.5	88.9	[34]
miR-29a + miR-29c + miR-133a + miR143 + miR-145 + miR-192 + miR-505	Serum	49 HCC vs 42 IHC + 48 HC	Chinese	qRT-PCR	0.884	85.7	91.1	[34]
miR-29a + miR-29c + miR-133a + miR143 + miR-145 + miR-192 + miR-505	Serum	Nested cohort: 568 samples from 135 CHB/LC vs 100 samples from 27 HCC	Chinese	qRT-PCR	0.670	55.6	78.5	[34]

Abbreviations: AFP, alpha-fetoprotein; AUC, area under the curve; CH, chronic hepatitis; CHB, chronic hepatitis B infection; CHC, chronic hepatitis C infection; HC, healthy control; HCC, hepatocellular carcinoma; HCV, hepatitis C virus infection; IHC, inactive HBsAg carrier; LC, liver cirrhosis.