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. 2022 Sep 15;17:4277–4292. doi: 10.2147/IJN.S380259

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© 2022 Guan et al.

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Expression and level of SP-A in lung tissue and serum. (A) Immunohistochemical staining for SP-A shows positive staining for proteinaceous materials, type II alveolar epithelial cells, alveolar macrophages, and alveolar mucus. Magnification ×200. Scale bar indicates 50 μm. (B) Graph of the mean area % of immunoreaction to SP-A. (C) SP-A levels in lung tissue at four time points. (D) SP-A levels in serum at four time points. Results are expressed as mean ± SD and analyzed using One Way ANOVA followed by Bonferroni’s post-hoc test at P < 0.05 (n = 4–8). *P < 0.05, Nano-SiO₂ vs control, ^#P < 0.05, Nano-ITO vs control.