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. 2022 Sep 5;13:988125. doi: 10.3389/fimmu.2022.988125

Figure 4.

Figure 4

Phenotypic changes in DN2 cells with Severe SARS-CoV-2 infection. (A) Representative histograms depicting expression of BAFFR, CD69, CD86, CD72, CD22 and FcRL5 on DN2 cells from a healthy control (HC), individual immunized against SARS-CoV-2 or individuals with mild or severe SARS-CoV-2 infection. Control dotted histogram is an FMO for CD69, CD68, CD72 and CD22. Control dotted histogram for BAFFR and FcRL5 is expression on CD3+ T cells from a healthy control subject. (B) Quantification of BAFFR, CD69, CD86, CD72, CD22 and FcRL5 expression (gMFI: geometric mean fluorescent intensity) on DN2 cells from healthy controls (HC), those immunized against SARS-CoV-2 (IM), or individuals with mild or severe SARS-CoV-2 infection. (C) Pie charts depicting the average frequency of IgM+, IgG+, or IgG-IgM- DN2 cells for healthy controls (HC, N=10), individuals immunized against SARS-CoV-2 (N=15), and individuals with mild (N=11) or severe SARS-CoV-2 infection (N=14). Statistics: one-way ANOVA, *p < 0.05, **p < 0.01.