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. 2022 Sep 5;13:988125. doi: 10.3389/fimmu.2022.988125

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Copyright © 2022 Castleman, Stumpf, Therrien, Smith, Lesteberg, Palmer, Maloney, Janssen, Mould, Beckham, Pelanda and Torres

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The alteration in the frequency of Double Negative populations correlates with increased systemic inflammation during Severe SARS-CoV-2 infection. (A) Correlation of systemic cytokine levels (CRP, TNFα, IL-6, IFNγ, IL-1β) in individuals immunized against SARS-CoV-2 (grey circles, N=8), individuals with mild (pink circle, N=9) and severe SARS-CoV-2 infection (red circle, N=12) with frequency of DN1 cells, (B) frequency of DN2 cells, or (C) frequency of DN3 cells within total double negative population (CD27-IgD-). Statistics: Pearson correlation, r and p values noted on each panel.