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. 2022 Sep 19;17(9):e0274786. doi: 10.1371/journal.pone.0274786

Table 1. Background characteristics of the patients, primary and secondary outcomes of the salvage and amputation groups.

Salvage Amputation P-values
Patients (limbsa) 34 (34a) 11 (13a)
Age (years) 49.9 (7–75) 49.0 (23–95)
Sex (M:F) 28:6 7:4
OTA-OFC scorea 9.8 (6–14) 14.3 (8–15)
Pre-operative LEFS 79.4 (66–80) 72.7 (22–80)
Post-operative LEFS 49.5 (15–80) 33.1 (5–61) 0.025*
SF-8
Physical functioning 41.8 34.6 0.076
Role physical 42.2 33.3 0.026*
Bodily pain 49.2 44.5 0.107
General health 51.3 49.1 0.335
Vitality 50.9 46.8 0.076
Social functioning 44.8 38.5 0.060
Role emotional 45.1 39.4 0.050
Mental health 48.7 38.7 0.003*
Physical component summary 43.8 39.0 0.073
Mental component summary 48.2 41.3 0.042*
Number of operations 4.4 (2–8) 2.3 (1–6) 0.001*
Infection rate (%) 35.3 38.5 1.000
Rate of change in employment (%) 26.5 18.2 0.705

a Number of injured limbs

Data presented as mean (range). OTA-OFC summative score was calculated for the number of injured limbs.

* indicates a significant difference.

LEFS, lower extremity functional scale; OTA-OFC, Orthopedic Trauma Association Open Fracture Classification; SF-8, Short-Form 8