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. 2022 Sep 19;18(9):e1010782. doi: 10.1371/journal.ppat.1010782

Fig 5. IgY-RBD confers protection in Ad5-hACE2 transduced mice infected with SARS-CoV-2.

Fig 5

Mice were transduced with Ad5-hACE2 and treated with IgY-RBD or IgY-control or PBS 2 hours prior to challenge with 2019-nCoV/USA-WA1/2020 SARS-CoV-2. (A) Weights were measured daily. IgY-control (red squares; n = 6), IgY-RBD (blue squares; n = 7) antibodies or PBS (black squares; n = 4) (B) Virus titers in the lungs were measured at the indicated times post infection. Each symbol represents data obtained from one individual mouse. Data in (A) are mean ± s.e.m. Data in (B) are geometric mean ± geometric SD. P values determined by two-tailed Student’s t test. Data are from one experiment.