Fig 7. IgY-RBD confers in vivo protection in SARS2-N501YMA30-infected BALB/c mice.
Male and female mice were treated with IgY-RBD or IgY-control or PBS at the indicated times prior to intranasal challenge with SARS2-N501YMA30. (A, B) Weight (A) and survival (B) were monitored daily. (C) Levels of infectious virus in the lungs were determined at 5 days post infection. (A and B) Male: n = 4 for PBS, IgY-control 0hpi and IgY-RBD 0hpi; n = 9 for IgY-control -24hpi and IgY-RBD -24hpi. Female: n = 4 PBS, IgY-control -12hpi; n = 5 IgY-control -24hpi, IgY-RBD (0hpi, -12hpi, -24hpi); n = 8 IgY-control 0hpi. (C) each symbol represents data obtained from one individual mouse. Data in (A) are mean ± s.e.m. Data in (C) are geometric mean ± geometric SD. P values determined by two-tailed Student’s t test. Data are pooled from three independent experiments.