Fig 8. IgY-RBD diminishes pathological changes in mice infected with SARS2-N501YMA30.
Lungs were harvested from mice treated with PBS, IgY-control or IgY-RBD at 5dpi. (A) Pulmonary edema (*) was widespread in PBS and IgY-control groups but was detected less in IgY-RBD-treated mice. Increased cellular infiltrates (arrows) in interstitial and perivascular regions were seen in the IgY-RBD group. HE stain, Bar = 480 and 95mm, top and bottom panels, respectively. (B) Ordinal scoring of lung edema. The median scores of the three groups varied significantly (P = 0.0317, Kruskal-Wallis test) and IgY-RBD trended to have reduced edema compared to PBS and IgY-control groups (P = 0.0892 and P = 0.0935, respectively, Dunn’s Posttest).