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. 2022 Sep 7;20(9):e3001782. doi: 10.1371/journal.pbio.3001782

Fig 9. Diagram of the function of the CEP90, FOPNL, and OFD1 in distal appendages assembly.

Fig 9

In G1, the complex composed of MNR, CEP90, FOPNL, and OFD1 is localized at both mother (MC) and daughter (DC) centrioles. During centriole duplication (S phase), the complex is recruited on the 2 procentrioles (PC) at the distal position, which is correlated with the future position of distal appendage protein CEP83. During G2/M, the procentrioles elongate maintaining the complex distally. The ancient daughter centriole matures in a mother one, by losing DCP and assembling distal appendages, where the complex is localized. When one of the proteins of this complex (CEP90, FOPNL, and OFD1) is depleted, none of these proteins is recruited to the centriolar wall leading to defective distal end appendage assembly and defective ciliogenesis. We propose that this complex is required to dictate on the procentriole the future location of distal appendage assembly.