. 2022 Sep 19;21(1):447–477. doi: 10.1007/s10311-022-01509-7

Table 3.

Utilization of cyclodextrin-based metal–organic frameworks and cyclodextrin-composites as drug vehicles

CD-MOF/ CD-MOF composites	CD	Metal salt	Metal ion	Synthesis method	Drug	Loading capacity	References
Nano ssCGP	γ-CD	KOH	K⁺	Vapor diffusion	Doxorubicin	45 mg/g	Xue et al. (2019)
RGD-functionalized CD-MOF	γ-CD	KOH	K⁺	Vapor diffusion	Doxorubicin	14%	Chen et al. (2021a)
Micro/nano cubic DPC-γ-CD-MOF sponges	γ-CD	KOH	K⁺	Vapor diffusion	Doxorubicin	60 – 80 mg/g	Singh et al. (2017)
γ-CD-MOF	γ-CD	KOH	K⁺	Vapor diffusion	Folic acid	35 wt%	Xu et al. (2019)
K-γ-CD Na-γ-CD Fe-γ-CD	γ-CD	KOH NaCl FeCl₃	K⁺ Cl⁻ Fe³⁺	Vapor diffusion	Diclofenac sodium	50% 49% 55%	Abuçafy et al. (2018)
γ-CD-MOF	γ-CD	KOH	K⁺	Vapor diffusion	Florfenicol Enrofloxacin	54.60 mg/g 45.25 mg/g	Wei et al. (2021)
CD-MOF	γ-CD	KOH	K⁺	Vapor diffusion	Ibuprofen	23 – 26 wt%	Hartlieb et al. (2017)
γ-CD-MOF-b	γ-CD	KOH	K⁺	Vapor diffusion	Acetaldehyde	30 µg/g	Al-Ghamdi et al. (2016)
γ-CD-MOF	γ-CD	KOH	K⁺	Vapor diffusion	Methotrexate	~ 6 wt%	Kritskiy et al. (2020)
CD-MOF-Micro CD-MOF-Nano	γ-CD	KOH	K⁺	Microwave-assisted	Sucralose	17.5% 27.9%	Lv et al. (2017)
CD-MOF-1	γ-CD	KOH	K⁺	Microwave-assisted	Fenbufen	196 mg/g	Liu et al. (2017a)
Nano-γ-CD-MOF	γ-CD	KOH	K⁺	Vapor diffusion	18β-glycyrrhetinic acid	17.2%	Liu et al. (2022)
KAc-γ-CD-MOF (dense) KAc-γ-CD-MOF (porous)	γ-CD	KAc	K⁺	Two steps 1. Hydrothermal synthesis 2. Crystal transformation	Valsartan	33.5% 30.2%	Ding et al. (2019)
CD-MOF	γ-CD	KOH	K⁺	Vapor diffusion	Scutellarin	30.42%	Zhao et al. (2020b)
γ-CD-MOF	γ-CD	KNO₃	K⁺	Vapor diffusion	Menthol	~ 11%	Hu et al. (2021)
KAc-γ-CD-MOF-THY-HT KOH-γ-CD-MOF-THY-HT KCl-γ-CD-MOF-THY-HT	γ-CD	KAc KOH KCl	K⁺	Hydrothermal	Thymol	293.8 mg/g 287.7 mg/g 249.3 mg/g	Pan et al. (2022)
β-CD-MOF	β-CD	Na₂C₂O₄	Na⁺	Solvothermal	5-Fluorouracil	23.02%	Lu et al. (2015)
β-CD-MOF-1 β-CD-MOF-2	β-CD	CsCl	Cs⁺	Template-induced approach	5-Fluorouracil Methotrexate 5-Fluorouracil Methotrexate	1.379 g/g 0.689 g/g 1.510 g/g 1.217 g/g	Liu et al. (2017c)
β-CD-MOF	β-CD	KOH	K⁺	Hydrothermal	Naringin	82.3%	Li et al. (2021a)
β-CD-MOF-IC	β-CD	KOH	K⁺	Vapor diffusion	Menthol	30.60%	Hu et al. (2022b)
β-CD-MOF	β-CD	KOH	K⁺	Vapor diffusion method	Quercetin Emodin	103.6 mg/g 177.26 mg/g	Kong et al. (2019)
β-CD-MOF	β-CD	KOH	K⁺	Vapor diffusion	Ibuprofen	7.4 wt%	Volkova et al. (2020)
SHPs@β-CDMOF β-CD-MOF@SHPs	β-CD	KCl	K⁺	Vapor diffusion	Curcumin	1.78% 1.49%	Shao et al. (2022)
K- β-CD -MOF Cs- β-CD -MOF	β-CD	KOH	K +	Vapor diffusion	Myricetin	282.39 mg/g 308.65 mg/g	Jiang et al. (2021)
β-CD -MOF	β-CD	KNO₃	K⁺	Vapor diffusion	Menthol	21.76%	Hu et al. (2021)
β-CD-MOF	β-CD	KOH	K⁺	Vapor diffusion Solvothermal	Dimercaptosuccinic acid	15%	Xiong et al. (2019)
α-CD-MOF-1 α-CD-MOF-2	α-CD	KOH	K⁺	Vapor diffusion Solvothermal	5-Fluorouracil	0.257 g/g 0.107 g/g	Sha et al. (2016)
α-CD-MOF	α-CD	KNO₃	K⁺	Vapor diffusion	Menthol	~ 5%	Hu et al. (2021)

The synthesis methods and materials of CD-MOF/ CD-MOF composites are summarized. Potential loaded drugs and the loading capacity of each CD-MOF/ CD-MOF composite are explained. CD-MOF refers to a cyclodextrin-based metal–organic framework, CD refer to cyclodextrin, ssCGP refers to novel cubic gel particles, KAc refers to Potassium acetate, KOH refers to potassium hydroxide, DPC refers to diphenyl carbonate-crosslinked, and SHPs refer to soybean hull polysaccharides