Skip to main content
. 2022 Aug 23;99(8):e775–e788. doi: 10.1212/WNL.0000000000200667

Figure 2. Whole-Brain Voxel-Wise Novelty Activation Pattern in Cognitively Normal Older Adults.

Figure 2

(A) Higher fMRI activity for novel than familiar scenes in cognitively normal older adults (N = 163) is seen in a frontal network, the supplementary motor cortex, the medial temporal lobe including the hippocampus and parahippocampal cortex, and the occipital regions bilaterally. (B) Lower fMRI activity for novel compared with familiar scenes (i.e., novelty-related deactivation) is seen in the posterior midline, lateral temporal, temporo-parietal, and frontal regions. Results are depicted at <0.05 (FWE, cluster-level, cluster-forming threshold p = 0.001).