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. 2022 Sep 15;14:2749–2761. doi: 10.2147/CMAR.S373271

Figure 1.

Figure 1

Synergistic effect of Ad-VT and cyclophosphamide. (A) Analysis of the cytotoxic effects of different doses of Ad-VT and cyclophosphamide on MCF-7 cells using the CCK-8 assay. The cell inhibition rate was calculated using the following formula: cell inhibition rate = [(Ac–As)/(Ac–Ab)] × 100%, where As is the experimental well containing cells with CCK-8 added; Ac is the control well containing cells with CCK-8 added; Ab is the blank well with CCK-8 and no cells. (B) Analysis of Ad-VT and cyclophosphamide synergistic concentrations in MCF-7 cells using the CalcuSyn software. (C) Analysis of the cytotoxic effects of different doses of Ad-VT and cyclophosphamide on MDA-MB-231 cells using the CCK-8 assay. (D) Analysis of Ad-VT and cyclophosphamide synergistic concentrations in MDA-MB-231 cells using the CalcuSyn software. Data are representative of three independent experiments (n = 3). (#P < 0.05, ##P < 0.01, when compared with the 20 MOI Ad-VT groups); *P < 0.05, **P < 0.01, ***P < 0.001.