Table 2. Results of the biochemical analysis of the inner cheek and tongue tissues.

Biochemical		Mean±standard deviation				p-values
parameters		HG	MTXG	TMTX	HG vs. MTXG	HG vs. TMTX	MTXG vs. TMTX
Inner cheek	MDA	3.32±0.11	6.14±0.20	3.56±0.12	<0.001	0.036	<0.001
	tGSH	5.67±0.13	2.54±0.22	5.10±0.22	<0.001	<0.001	<0.001
	TNF-α	2.13±0.08	5.09±0.25	2.44±0.08	<0.001	<0.001	<0.001
	IL-1β	1.26±0.07	3.58±0.35	1.52±0.14	<0.001	0.011	<0.001
	IL-6	1.73±0.07	3.92±0.20	1.83±0.20	<0.001	0.432	<0.001
Tongue	MDA	4.13±0.58	6.88±0.16	4.37±0.23	<0.001	0.630	<0.001
	tGSH	5.34±0.16	2.20±0.12	4.76±0.19	<0.001	<0.001	<0.001
	TNF-α	2.29±0.10	4.70±0.95	2.45±0.08	<0.001	0.020	<0.001
	IL-1β	1.42±0.07	3.81±0.09	1.65±0.09	<0.001	0.001	<0.001
	IL-6	2.02±0.24	4.20±0.31	2.22±0.19	<0.001	0.374	<0.001

MDA: malondialdehyde; tGSH: total glutathione; TNF-α: tumor necrosis factor alpha; IL-1β: interleukin 1 beta; IL- 6: interleukin 6: HG: healthy group; MTXG: methotrexate group: TMTX: taxifolin+methotrexate group. The analysis was performed by one-way ANOVA and the Tukey or Games-Howell test was used as a post hoc test.