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. 2022 Sep 16;71(37):1182–1189. doi: 10.15585/mmwr.mm7137a4

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The figure is a line graph showing the monthly crude mortality risk for non–COVID-19 hospitalizations, total COVID-19 hospitalizations, hospitalizations primarily for COVID-19, and hospitalizations not primarily for COVID-19 in the United States from April to June 2022 according to the Premier Healthcare Database Special COVID-19 Release from August 2, 2022. — Crude mortality risk* for total COVID-19 hospitalizations, hospitalizations primarily for COVID-19, hospitalizations not primarily for COVID-19,^† and non–COVID-19 hospitalizations — Premier Healthcare Database Special COVID-19 Release,^§ United States, April 2020–June 2022^¶

* In-hospital mortality was defined by a discharge status of expired. Crude mortality risk was calculated as in-hospital deaths per 100 hospitalizations.

^† Total COVID-19 hospitalizations are those with a primary or secondary discharge diagnosis of COVID-19 (i.e., International Classification of Diseases, Tenth Revision, Clinical Modification code of U07.1). Non–COVID-19 hospitalizations are those without a COVID-19 discharge diagnosis. Hospitalizations primarily for COVID-19 had a primary discharge diagnosis of COVID-19 or a secondary discharge diagnosis of COVID-19 accompanied by either treatment with remdesivir or a primary discharge diagnosis of sepsis, pulmonary embolism, acute respiratory failure, or pneumonia. Hospitalizations not primarily for COVID-19 are those that did not meet criteria for a hospitalization primarily for COVID-19.

^§ August 2, 2022, data release. Data are from 678 hospitals that had at least one inpatient record per month during April 2020–May 2022.

^¶ Variant pandemic periods were selected based on two factors: 1) the U.S. epidemic curve for new admissions of patients with confirmed COVID-19 (https://covid.cdc.gov/covid-data-tracker/#new-hospital-admissions) and 2) the U.S. variant proportions from SARS-CoV-2 genomic surveillance (https://data.cdc.gov/Laboratory-Surveillance/SARS-CoV-2-Variant-Proportions/jr58-6ysp). Pandemic periods are defined using whole months because of date aggregation in the data source. The Delta variant (B.1.617.2) became the predominant circulating strain (representing >50% of sequenced isolates) during the week ending June 26, 2021, the Omicron B.1.1.529 subvariant became the predominant circulating strain during the week ending December 25, 2021, and the Omicron BA.2 subvariant became the predominant circulating strain during the week ending March 26, 2022. The predominant circulating strains during the early Omicron period were B.1.1.529 and BA.1 and during the later Omicron period were BA.2 and BA.2.12.1.