. 2022 Sep 20;8(9):e10702. doi: 10.1016/j.heliyon.2022.e10702

Table 2.

In vitro studies on the effect of PCs against different SARS-CoV-1 (^a) and SARS-CoV-2 (^b) targets.

Reference	Source	Compound	Target proteins	IC50 value
Annunziata et al. (2020)	N.S.	Gallocatechin gallate and catechin gallate	N protein^a	500 μg/L (40% inhibition)
Lee et al. (2009)	N.S.	Quercetin	NTPase/helicase^a	8.1 μM
Llivisaca-contreras et al. (2021)	Scutellaria baicalensis	Myricetin	nsP13 helicase^a	2.71 μM
Mani et al. (2020)	Broussonetia papyrifera	3′-(3-methylbut-2-enyl)-3′,4,7-trihydroxyflavane	PLpro^a	3.7 μM
Piccolella et al. (2020)	Psoralea corylifolia L. seeds	Psoralidin	PLpro^a	4.2 μM
	Psoralea corylifolia L. seeds	Isobavachalcone	PLpro^a	7.3 μM
	Psoralea corylifolia L. seeds	4′-O-methylbavachalcone	PLpro^a	10.1 μM
	Psoralea corylifolia L. seeds	Bavachinin	PLpro^a	38.4 μM
	Betula papyrifera roots	Papyriflavonol A	PLpro^a	3.7 μM
	Angelica keskei leaves	Xanthoangelol E	PLpro^a	1.2 μM
	Angelica keskei leaves	Coumarins	PLpro^a	>200 μM
Siddiqui et al. (2020)	Paulownia tomentosa fruit	Tomentin E	PLpro^a	5 μM
Mehany et al. (2021)	Torreya nucifera leaves	Luteolin	3CLpro^a	20.2 μM
	Torreya nucifera leaves	Apigenin	3CLpro^a	280.8 μM
	Brown algae	Dieckol	3CLpro^a	2.7 μM
	Isatis indigotica roots	Sinigrin	3CLpro^b	217 μM
	Isatis indigotica roots	Hesperetin	3CLpro^b	8.3 μM
	Torreya nucifera leaves	Quercetin	3CLpro∗	23.8 μM
Park et al. (2013)	Ecklonia cava	Phlorotannins	3CLpro^a	2.7 to >200 μM
Russo et al. (2020)	N.S.	Quercetin-3-β-galactoside	3CLpro^a	42.79 μM
	Torreya nucifera leaves	Amentoflavone	3CLpro^a	8.3 μM
	N.S.	Tomentin A-E	3CLpro^a	5.0–14.4 μM
Paraiso et al. (2020)	Rheum officinale roots	Emodin	S protein-ACE2^a	200 μM
Yu et al. (2012)	Aglaia perviridis	Myricetin	nsP13 ATPase^a	2.71 μM
	Aglaia perviridis	Scutellarein	nsP13 ATPase^a	0.86 μM

N.S.: Not specified.