Table 3.
Levels of kidney function parameters in different groups.
| Parameters | Time | Groups | |||
|---|---|---|---|---|---|
| Healthy Mean ± S.D. |
DM + vehicle Mean ± S.D. |
DM + Lys Mean ± S.D. |
Healthy + Lys Mean ± S.D. |
||
| Serum creatinine (mg/dL) | Four weeks | 0.75 ± 0.9# | 7.40 ± 0.47 | 5.87 ± 1.04 | 0.92 ± 0.95# |
| Eight weeks | 0.766 ± 0.9# | 7.71 ± 0.57 | 1.058 ± 0.7# | 0.863 ± 0.27# | |
|
| |||||
| Blood urea nitrogen (mg/dL) | Four weeks | 24.73 ± 2.32# | 115.9 ± 2.06 | 95.72 ± 1.09 | 25.95 ± 1.09# |
| Eight weeks | 24.74 ± 2.32# | 165.04 ± 4.53 | 43.03 ± 1.4# | 24.22 ± 3.06# | |
|
| |||||
| Glomerular filtration rate (cc/min) | Four weeks | 2.64 ± 0.003# | 0.045 ± 0.001 | 1.42 ± 0.24∗ | 2.66 ± 0.009# |
| Eight weeks | 3.01 ± 0.003# | 0.031 ± 0.002 | 1.75 ± 0.20# | 3.02 ± 0.009# | |
|
| |||||
| Urine microalbumin (μg/dL) | Four weeks | 60.1 ± 10.52# | 663.87 ± 73.9 | 660.25 ± 70.9 | 59.90 ± 10.5# |
| Eight weeks | 62.39 ± 13.58# | 1680.98 ± 115.35 | 740.35 ± 73.98# | 60.35 ± 10.5# | |
|
| |||||
| Kidney weight (gr) | Four weeks | 66.45 ± 11.58# | 2045.42 ± 167.92 | 803.5 ± 10.53# | 64.78 ± 11.32# |
| Eight weeks | 0.71 ± 0.07# | 1.37 ± 0.15 | 1.01 ± 0.09# | 0.75 ± 0.07# | |
#: Significant difference with the DM + vehicle group at a level of <0.001. ∗: Significant difference with the DM + vehicle group at a level of <0.05.