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. 2022 Aug 18;323(4):F455–F467. doi: 10.1152/ajprenal.00181.2022

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Published by the American Physiological Society.

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Figure 2. — Aristolochic acid (AA) decreased renal mRNA expression of proximal tubule amino acid transporters. Kidney mRNA expression of Slc6a19 (B⁰AT1; A), Slc6a15 (B⁰AT2; B), Slc6a18 (B⁰AT3; C), and Slc7a9 (D) in mice treated with vehicle or AA. mRNA expression was normalized to the ribosomal protein L19 (Rpl19) gene. Values are means ± SE and dots show individual mouse data. Two-way ANOVA was performed to probe for a significant effect of treatment (P_AA), genotypes (P_Slc6a19), or the interaction between the two factors (P_inter). If the interaction was statistically significant, then a pair-wise multiple comparison procedure (Holm–Sidak method) identified the significant effects. *P < 0.05 vs. wild-type (WT) mice; #P < 0.05 vs. vehicle. n = 7–14 mice/group.