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. 2022 Aug 18;323(4):F455–F467. doi: 10.1152/ajprenal.00181.2022

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Published by the American Physiological Society.

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Figure 3. — Absence of B⁰AT1 did not affect the aristolochic acid (AA)-induced reduction in body and organ weight, hematocrit, or an estimate of glomerular filtration rate. A: body weight under basal conditions (n = 18–30 mice/group, pooled groups before injection of vehicle or AA), after injections (INJ), and at harvest. B: kidney, heart, and liver weight at harvest. C: hematocrit under basal conditions (n = 19–28 mice/pooled group), after injections, and at harvest. D: plasma creatinine (Pcrea) under basal conditions (n = 19–30 mice/pooled group), after injections, and at harvest. Values are means ± SE and dots show individual mouse data. For basal conditions, one-way ANOVA was performed to probe for a significant effect of genotypes. For the other two time points, two-way ANOVA was performed to probe for a significant effect of AA treatment (P_AA), genotypes (P_Slc6a19), or the interaction between the two factors (P_inter). If the interaction was statistically significant, then a pair-wise multiple comparison procedure (Holm–Sidak method) identified the significant effects.