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Severe dysregulation of immunoglobulins in Nfkb2−/− mice. Small intestinal tissue lysates and sera from Nfkb2+/+ (black circles), Nfkb2+/− (black and white circles), and Nfkb2−/− mice (open circles) (n = 5 or 6/genotype) were used for quantification of immunoglobulins. Total protein in tissue lysates was used for normalization purpose. Kruskal–Wallis multiple-comparison test was applied. *P < 0.05, **P < 0.01.
