Table 2.
Comparison of cystometric parameters
| SCI With Vehicle (n = 5) | SCI With Soluble Guanylyl Cyclase (n = 6) | |
|---|---|---|
| Micturition pressure, cmH2O | 42.1 ± 2.1 | 38.3 ± 6.1 |
| Time to void, min | 44.4 ± 12.3 | 33.5 ± 9.2* |
| NVCs, number of NVCs/min | 0.9 ± 0.3 | 0.5 ± 0.1† |
| Time to first NVC, min | 15.1 ± 7.6 | 18.6 ± 4.2 |
| Voided volume, mL | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Postvoid residual, mL | 0.4 ± 0.1 | 0.3 ± 0.1* |
| Bladder capacity, mL | 0.5 ± 0.1 | 0.3 ± 0.1* |
| Bladder compliance, mL/cmH2O | 0.0 ± 0.0 | 0.1 ± 0.0 |
| Voiding efficiency, % | 6.5 ± 1.5 | 13.0 ± 4.0† |
Shown is a comparison of cystometric parameters in vehicle-treated (n = 5) and BAY 60-2770-treated spinal cord-injured (SCI) mice (n = 6). NVCs, nonvoiding contractions. *P < 0.05 compared with the SCI with vehicle-treated group; †P < 0.01 compared with the SCI with vehicle-treated group.