Figure 4.

Plasma measurements in wild-type (WT), Liddle, and pseudohypoaldosteronism type 1 (PHA1) mice at baseline and with chronic infusion of desmopressin (dDAVP). A: plasma aldosterone concentrations were not different with dDAVP infusion. Means (±SE) plasma aldosterone concentration was suppressed in Liddle mice with infusion of vehicle or dDAVP (100 ng/h) for 5 days. P < 0.05 by two-way ANOVA with Tukey’s correction for the effect of genotype. n = 6 WT mice, 6 Liddle mice, and 6 PHA1 mice with vehicle treatment; n = 7 WT mice, 6 Liddle mice, and 5 PHA1 mice with dDAVP treatment. B: means (±SE) plasma measurements in WT, Liddle, and PHA1 mice at baseline and with chronic infusion of dDAVP. Male mice were fed a regular chow diet or also administered dDAVP at 100 ng/h for 5 days. *P < 0.05 by two-way ANOVA with Tukey’s correction from other groups of mice. tCO₂, total CO₂.