Figure 4.

Effect of tissue-specific angiotensinogen (AGT) in glomerular basement membrane (GBM) thickening and foot process effacement in post-5/6 nephrectomy (Nx) kidneys. Kidney samples were collected at 16 wk post-Nx. A: electron microscopy was used to evaluate GBM thickening and foot process length. GBM thickness (B) and podocyte foot process length (C) were measured in at least 50 randomly chosen areas per kidney (n = 3–5). Scale bars = 500 nm. Data are expressed as means ± SD. ***P < 0.001 vs. the respective sham; ###P < 0.001. LKO, liver-specific AGT knockout; PKO, proximal tubule-specific AGT knockout; WT, wild type.