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. 2022 Aug 12;47(11):1939–1944. doi: 10.1038/s41386-022-01410-5

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© The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 1 — Gray straight line represents the time interval when the difference between the products was statistically significant (t-test, p < 0.05). Brain nicotine accumulation per kg of tissue mass was expressed as a percentage of the total absorbed dose (TAD) of ¹¹C-nicotine.