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. 2022 Aug 12;47(11):1939–1944. doi: 10.1038/s41386-022-01410-5

Fig. 2. Kinetic parameters (mean + SEM) of brain nicotine accumulation after inhalation of a single puff of E-cig vapor and C-cig smoke in dual users (n = 16).

Fig. 2

A The mean maximal nicotine concentration (Cmax); B The mean area under the time activity curve (AUC) from 0 to 15 min; C The mean time to reach the maximal nicotine concentration (Tmax); and D The mean time to reach one-half of the maximal nicotine concentration (T1/2). Brain nicotine accumulation per kg of tissue mass was expressed as a percentage of the total absorbed dose of 11C-nicotine (TAD). **p < 0.005 and ***p < 0.001 after correction for multiple comparisons.