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. 2022 Sep 19;5:989. doi: 10.1038/s42003-022-03938-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a U-map pseudotime analysis and lineage tracing of muscle cell types was performed for WT (n = 3), mdx e23AON (n = 4), and mdx (n = 4) nuclei. Muscle cell types are arranged according to their transcriptional relatedness and subcluster color is matched to legend for cell types shown in a and b. b Gene expression for selected genes distinguishing muscle cell subset populations plotted in a. Gray background indicates known markers of the respective cell type on x-axis. (Complete list of significantly different genes identifying each population is found in Supplementary Data 2). c Gene expression across treatment conditions is shown for select muscle cell/nuclei types. Yellow indicates higher gene expression. Heatmap of all genes significantly different between mdx and WT, demonstrates a strong trend toward a more WT pattern of expression in Satellite Cells, and Type IIa, IIx, and IIb myonuclei in e23AON-treated mdx.