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. 2022 Sep 19;79(10):524. doi: 10.1007/s00018-022-04541-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — ERK5 inhibition impairs growth of EC tumor xenografts in vivo. A Tumor growth curve of subcutaneous xenograft (Ishikawa cells), treated i.p. with either vehicle or 50 mg/Kg JWG-071 daily. N = 6 mice per group. Data are presented as mean ± SEM. ****, P < 0.0001, two-way ANOVA Bonferroni. B Immunohistochemical analysis of Ki67 expression of xenograft tumors. Right histograms show Ki67 quantification. ***, P < 0.001. C, Tumor growth curves. Nude mice bearing Ishikawa cell subcutaneous xenograft tumors were daily treated i.p. with either vehicle (n = 6) or 50 mg/Kg JWG-071 (n = 6). Values represent the mean ± SEM. *, P < 0.05; ***, P < 0.001, two-way ANOVA Bonferroni. Right panel shows the corresponding scatter plot for tumors at day 14 of treatment. D–E Immunoblot (D) and cleaved caspase-3 immunohistochemical (E) analysis of the endometrioid xenograft tumors. Histograms show the corresponding quantification. F Immunoblot analysis of NF-κB pathway proteins from xenograft tumors. Histograms show the corresponding quantifications. B, D–F *, P < 0.05; **, P < 0.01; ***, P < 0.001