. 2021 Nov 18;9(6):1579–1593. doi: 10.1016/j.gendis.2021.10.007

Table 2.

Alterations of RIP kinase expression in cancer.

RIP kinases	Alterations and cancer types	References
RIP1	• Downregulation: breast cancer, CRC, HNSCC • Upregulation: gallbladder cancer, gastric cancer glioblastoma, lung cancer, melanoma, PDA	³⁸^,⁷²^,⁷³^,77, 78, 79, 80, 81^,⁹⁷
RIP2	• Downregulation: OSCC • Upregulation: breast cancer, CRC, gastric cancer, KIRC	85, 86, 87, 88, 89, 90, 91
RIP3	• Downregulation: AML, breast cancer, CLL, CRC, lung cancer, malignant mesothelioma, melanoma, prostate cancer • Upregulation: PDA	³⁸^,⁸¹^,⁹⁴^,⁹⁵^,98, 99, 100^,¹⁰³
RIP4	• Downregulation: HCC, lung cancer, TSCC • Upregulation: bladder cancer, CSCC, CRC, osteosarcoma, ovarian cancer, pancreatic cancer	⁵⁸^,108, 109, 110^,113, 114, 115, 116, 117, 118, 119
RIP6	• Downregulation: HCC	¹²⁰

Abbreviations: AML: acute myeloid leukemia; CLL: chronic lymphocytic leukemia; CRC: colorectal cancer; HCC: hepatocellular carcinoma; HNSCC: head and neck squamous cell carcinoma; KIRC: kidney renal clear cell carcinoma; OSCC: oral squamous cell carcinoma; PDA: pancreatic adenocarcinoma; RIP: receptor interacting protein; TSCC: tongue squamous cell carcinoma.