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. 2021 Sep 1;9(6):1521–1555. doi: 10.1016/j.gendis.2021.08.003

Figure 2.

Figure 2

Architectural alignment and subcellular localization of CHIP. (A) The schematic diagram represents the architectural alignment of all the three domains (TPR, Ubox and Charged) of CHIP. TPR (tetratricopeptide repeats) domain is present at the N-terminus of CHIP, while Ubox domain is at C-terminus. The charged domain is localized in between TPR and Ubox domains of CHIP. (B) The diagram represents the sub-cellular localization of CHIP in endoplasmic reticulum (ER), mitochondria, cytoplasm, nucleus and golgi bodies.