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Molecular chaperones (HSP70/HSC70 and HSP90) dependent, independent and direct mechanisms of CHIP mediated degradation of client proteins. CHIP mediated degradation of client proteins through inhibition of either (A) HSP70/HSC70 mediated refolding; (B) HSP90 mediated refolding or, (C) Chaperones independent route for degradation of client proteins. Arrows indicate either positive (solid) or negative (T shaped) regulation.
