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. 2022 Apr 6;47(11):1976–1983. doi: 10.1038/s41386-022-01316-2

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Regions with significant User-Group or Age-Group differences during reward feedback in the whole-brain analysis, in n = 125 participants. Images are presented in radiological orientation, such that left on the image is the right hemisphere. Graphs display means and standard errors for reward feedback beta-values averaged across the given region, with individual values overlayed. A User-Group effect in right and left inferior parietal cortex. B User-Group effect in the right frontopolar cortex. C Age-Group effect in superior frontal gyrus. One-sample t-tests showed that individual group means were significantly different from zero, except for in cannabis users in the right inferior parietal cortex, and in adults in the superior frontal gyrus.