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. 2022 Sep 19;6:66. doi: 10.1038/s41698-022-00301-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Expression profile of functional genesets including antigen presenting cell abundece, T/NK cell abundence, IFN activity and T cell exhasution were presented through z-score. b Radar plots of comprehensive immune phenotypes including PD-L1 expression in PL, T-cell inflamed GEP and suppressor cell score in PL and DLNs were scaled into 0–100%. T_PD-L1 represents expression of PD-L1 in tumor; T_GEP represents gene-expression profile of infiltrating lymphocytes in tumor; T_SC represents suppressor cell in tumor; LN_GEP represents gene-expression profile of infiltrating lymphocytes in draining lymph nodes; LN_SC represents suppressor cell in draining lymph nodes. c Gene set enrichment analysis (GSEA) of PL and DLNs upon responders and non-responders.