Table 1.

Effects of manipulated XIST expression on cell proliferation and tumorigenesis in male-biased cancers.

Cancer types	Cell lines	Gender of cell host	Genetic manipulation in XIST expression	Effects on cell proliferation and/or tumorigenesis	References
Bladder cancer	5637	Male	Overexpression	Promotion	116
			Knockdown	Inhibition	105,118
	253J	Male	Knockdown	Inhibition	119
	T24	Female	Knockdown	Inhibition	105,116,118
	RT112	Female	Knockdown	Inhibition	119
Colorectal cancer	HT29	Female	Overexpression	Promotion	117
	LoVo	Male	Knockdown	Inhibition	117
	SW480	Male	Knockdown	Inhibition	109
	HCT116	Male	Knockdown	Inhibition	109
Non-small cell lung cancer	A549	Male	Overexpression	Promotion	114
			Knockdown	Inhibition	106,112, 113, 114,120,122, 123, 124
	H1299	Male	Overexpression	Promotion	114
			Knockdown	Inhibition	112, 113, 114,122, 123, 124
	H522	Male	Knockdown	Inhibition	121
	Calu3	Male	Knockdown	Inhibition	121
	H226	Male	Knockdown	Inhibition	120