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. 2021 Nov 19;9(6):1701–1715. doi: 10.1016/j.gendis.2021.11.003

Figure 3.

Fig. 3

Loss of G3bp2 reduces OSS-induced atherosclerotic lesion formation.(A) Plaque area in carotid artery in partial ligation Apoe–/–, G3bp2+/–Apoe–/– and G3bp2–/–Apoe–/– mice on a high-fat diet for 4 weeks were analyzed by en face ORO staining. (B) Percentage of lesion occupied area vs. total area of enface carotid from mice (n = 6). (C) Sections of the LCA were stained with H&E, ORO, Masson and toluidine blue staining. Scale bar, 100 μm. (D) Percentage of luminal surface occupied by lesion in carotid (n = 18 sections from 6 mice, 3 sections per mouse, including distal, middle and proximal carotid section). (E, F) Quantification of collagen area or necrotic area in lesion area in individual mice (n = 6). (G) Representative ORO stained descending aortas from Apoe–/–, G3bp2+/–Apoe–/– and G3bp2–/–Apoe–/– mice fed a normal diet for 35 weeks. Scale bar, 5 mm. (H) Quantitative analysis of the descending aorta, aortic arch, thoracic aorta and abdominal aorta is shown (n = 6). All values are mean ± SEM and are analyzed by one-way ANOVA followed by Bonferroni's multiple comparison test. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ns, not significant.