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. 2021 Nov 19;9(6):1701–1715. doi: 10.1016/j.gendis.2021.11.003

Figure 6.

Fig. 6

Deficiency of G3BP2 reduces leakage of EC layer.(A) Representative images showing Evans blue dye in descending aortas of Apoe–/– and G3bp2+/–Apoe–/– mice. (B) Quantification of the OD 620 nm of Evans blue in the aortas (n = 9). Values are mean ± SEM and are analyzed using the unpaired two-tailed Student's t-test. ∗∗∗P < 0.001. (C) Morphological analysis of VE-Cadherin used for manual classification in five categories: fingers, straight, thick, thick/reticular and reticular adherence junctions. (D) Representative images showing immunofluorescence of VE-Cadherin in HUVECs treated with OSS. (E) Morphological assessment of VE-Cadherin in HUVECs (n = 5). Values are mean ± SEM and are analyzed by one-way ANOVA followed by Bonferroni's multiple comparison test. Scale bar, 20 μm ∗∗P < 0.01; ∗∗∗P < 0.001.