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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Transl Stroke Res. 2022 Mar 20;13(6):1017–1036. doi: 10.1007/s12975-022-01007-6

Fig. 7: Ascorbate Increased Expression of Neuroprotective Genes after Stroke in a TET3-dependent Manner.

Fig. 7:

SiRNA (TET3 or Negative control siRNA) was injected 48h before the induction of MCAO. Saline or ascorbate (500 mg/kg; i.p.) was injected at 30 min reperfusion in adult mice following transient MCAO. (A) Expression of selected genes involved in ischemic outcome that displayed significant DhMRs in male and (B) female mice at 48h reperfusion. *p<0.05 compared to Sal/Neg siRNA group and #p<0.05 compared with Asc/Neg siRNA group by one-way ANOVA followed by Tukey’s post-test. n=3/group.