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. Author manuscript; available in PMC: 2023 Dec 1.
Published in final edited form as: Transl Stroke Res. 2022 Mar 20;13(6):1017–1036. doi: 10.1007/s12975-022-01007-6

Fig. 9: Ascorbate Decreased Pathophysiological Markers after Stroke via TET3.

Fig. 9:

SiRNA (TET3 or Negative control siRNA) was injected 48h before the induction of MCAO. Saline or ascorbate (500 mg/kg; i.p.) was injected at 30 min reperfusion in adult mice following transient MCAO. Immunostaining of markers of (A) oxidative stress (3-NT), (B) mitochondrial fragmentation (p-Drp1) and (C) apoptosis (cleaved caspase-3; Cas-3) in the NeuN+ cells (neuronal) in the cortical peri-infarct region of adult mice at 3 days reperfusion. n=3/group; Scale bar is 15 μm.