Table 1:
Ascorbate/TET3 modulated DhMRs in the promoters of genes putatively involved in cell survival and post-ischemic outcome.
| Gene | Putative function |
|---|---|
| AMH | Hormone, promotes neuroserpin expression and reduces infarct volume after cerebral ischemia |
| IRF8 | Transcription factor, attenuates neuronal apoptosis oxidative stress and inflammation after ischemia |
| INSR | Insulin receptor, mediates signaling that improves neuronal survival |
| LANCL | Glutathione transferase, protects neurons against oxidative stress and prevents apoptosis. |
| PRLR | Neuropeptide, attenuates edema and reduces infarct |
| SFRP4 | Binding protein, decreases pro-apoptotic proteins following ischemia |
| SH3BP5L | Mitochondrial membrane protein, provides endogenous protection in neuronal cells |
| DGAT1 | Metabolic enzyme, reduces inflammation, lipid toxicity and improves recovery after ischemia in cardiomyocytes |
| GFRA4 | Cell receptor, promotes neuronal survival through PI-3 kinase/AKT activation which prevents apoptosis |
| PPPR14A | Phosphatase, expression associated with neuroprotection after stroke |
| TPT1 | Prevents apoptosis, DNA damage and promotes survival following oxidative stress |
| SLA2 | Adapter protein, immune regulator that provides endogenous protection against focal cerebral ischemia |
| Kcnk16 | Potassium channel, may be important in brain repair after cerebral ischemia |
| TRHR | Hormone receptor, signaling prevents oxidative stress, apoptosis and is neuroprotective following ischemia |
| PDGFB | Growth factor, promotes collateralization and reduces oxidative stress following cerebral ischemia |
AMH, muellerian-inhibiting factor precursor; IRF8, interferon regulatory factor 8; INSR, insulin receptor; LANCL, lanC-like protein 1, (lanthionine synthetase-like protein-1); PRLR, prolactin; SFRP4, secreted frizzled-related sequence protein 4 precursor; SH3BP5L, SH3 domain-binding protein 5; DGAT1, diacylglycerol O-acyltransferase 1; GFRA4, GDNF family receptor alpha-4 isoform 4; PPP1R14A, protein phosphatase 1 regulatory subunit 14A; TPT1, translationally-controlled tumor protein; SLA2, src-like-adapter 2; KCNK16, potassium channel, subfamily K, member 16; PDGFB, platelet-derived growth factor subunit B.