TABLE 3.

$\mathrm{\Delta }\mathrm{\Delta }{G}_{L_1\to L_2}^{\mathit{bind}}$ for the mutations l51c → l51d, l51e → l51f in the FXa model system along two different paths (see also Figure 4).

Mutation	$\mathrm{\Delta }\mathrm{\Delta }{G}_{L_1\to L_2}^{\mathit{bind}}$ (path 1)	$\mathrm{\Delta }\mathrm{\Delta }{G}_{L_1\to L_2}^{\mathit{bind}}$ (path 2)	$\mathrm{\Delta }\mathrm{\Delta }{G}_{L_1\to L_2}^{\mathit{bind}}$ (exp)
l51c → l51d	4.03 ± 0.7	4.21 ± 1.1	3.36
l51e → l51f	−0.87 ± 0.5	−0.79 ± 1.5	−2.32