TABLE 1.

Progression of echocardiographic parameters during normal sinus rhythm after 12-weeks of persistent ventricular bigeminy.

Group	Sham N = 9	PVC N = 11	P-value (across groups)
LVEF (%) Mean ± SD
Baseline	60.4 ± 6.4	62.1 ± 4.6	0.58
Week-4	55.1 ± 4.4	50.9 ± 4.8	0.002
Week-8	55.6 ± 4.3	43.9 ± 7.9	< 0.001
Week-12	59.1 ± 5.1	41.5 ± 7.1	< 0.001
P-value (within group)	0.1	<0.001
Peak global circumferential strain
Baseline	–18.8 ± 3.5	–18.8 ± 3.3	0.9
Week-4	–20.1 ± 4.2	–14.1 ± 3.6	0.004
Week-8	–20.9 ± 3.8	–13.2 ± 1.8	<0.001
Week-12	–18.4 ± 3.4	–11.8 ± 3.0	<0.001
P-value (within group)	0.38	<0.001
Inter-ventricular dyssynchrony
Baseline	30 ± 10.4	27.5 ± 15.8	0.69
Week-12	37.2 ± 15.9	32.3 ± 22	0.37
P-value (within group)	0.28	0.57
Intraventricular dyssynchrony
Baseline	52.9 ± 31.9	48.7 ± 31	0.94
Week-4	48.1 ± 37.4	122.3 ± 103.4	0.07
Week-8	41.9 ± 37.5	56.7 ± 41.3	0.65
Week-12	63.4 ± 37.5	63.3 ± 34.4	0.95
P-value (within group)	0.59	0.03
Electromechanical latency
Baseline	199.2 ± 37.8	219.4 ± 36.9	0.29
Week-4	207.7 ± 21.1	249.2 ± 54	0.07
Week-8	214.0 ± 38.3	276.0 ± 45.9	0.009
Week-12	218 ± 36.7	283.2 ± 46.3	0.001
P-value (within group)	0.67	0.01

Data presented in mean ± standard deviation (P-value, one-way ANOVA within and across groups). PVC, Premature ventricular contraction.