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. 2022 Sep 6;12:933248. doi: 10.3389/fonc.2022.933248

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Copyright © 2022 Hu, Wang, Su, Zhang and Kou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) CCDC26 knockout upregulates the expression of C-KIT and IGF-1R in IM-resistant GISTs. (B) Additive antiproliferative and proapoptotic effects are obtained after the combined inhibition of IR and KIT in IM-resistant GIST cells. (C) Upregulation of IGF-1R leads to drug resistance through the PI3K/AKT/MDM2 signaling pathway.