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. 2022 Sep 20;121(11):3287–3303. doi: 10.1007/s00436-022-07660-y

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Fig. 4 — Release of mRNA and protein into extracellular medium by N. fowleri trophozoites. (a) mRNA release by trophozoites interacted with PMNs was localized in contact with PMNs alone or co-localized with cathepsin B (turquoise and gray arrows, respectively), whereas protein was in pseudopods a food-cups (brown and yellow arrows, respectively). (b) In tissue sections of infected mice, trophozoites expressed mRNA within small vesicles distributed in cytoplasm (blue arrows), but their release could not be observed, whereas cathepsin B release was observed within small vesicles (red arrows). (c) mRNA and protein distribution shown in 3D images (blue and white arrows, respectively). All 3D images were taken from the magnification of figure b. L, lumen. C, cartilage. RE, respiratory epithelium. Images are displayed at 40x (scale bar, 20 μm) and 100x (scale bar, 10 μm)