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Linear representation of the domains of PLCγ2. PLCG2 M28L and P522R variants are shown in the domain architecture. N amino-terminus, C carboxyl-terminus, PH: pleckstrin homology domain, EF: EF-hand motif, TIM: TIM barrel, sPH: split PH domain, nSH2: n-terminus Src Homology two domain, cSH2: c-terminus Src Homology two domain, SH3: SRC Homology three domain, C2: C2 domain.
