Table 1.

Effects of different doses of rosuvastatin (Ros), tramadol (Tra), etoricoxib (Eto), amlodipine (Aml), and amitriptyline (Ami) on tail-flick latency in mice in phase I.

		0 h		0.5 h		1 h		2 h		3 h		4 h		5 h		6 h
		Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD	Mean	SD
Eto	10 mg	3.17	0.408	3.67	0.816	3.83	0.753	3.67	0.516	3.33	0.516	3.17	0.753	3	0.632	–	–
	20 mg	3.33	0.516	3.67	0.516	5.83	0.753	5.33	0.516	4.17	0.753	3.83	0.753	3.33	0.516	–	–
	40 mg	3.33	0.516	3.67	1.033	7.17	1.169	6.33	0.516	4.33	0.816	3.67	0.516	3.33	0.516	–	–
	p-value	0.791		0.999		<0.001		<0.001		0.059		0.245		0.505		–
Aml	2.5 mg	3.17	0.753	3.33	0.516	3.5	0.548	3.83	0.753	3.67	0.516	3.5	0.548	3.33	0.516	3.17	0.753
	5 mg	3.33	0.516	3.67	0.516	3.83	0.408	4.17	0.408	7.67	0.516	5.67	0.516	4.17	0.753	3.17	0.753
	10 mg	3.33	0.516	3.5	0.548	4.17	0.753	4.33	0.516	7.83	0.753	5.67	0.516	4.17	0.753	3.17	0.753
	p-value	0.861		0.561		0.179		0.338		<0.001∗		<0.001∗		0.082		0.999
Tra	5 mg	3.5	0.548	3.67	0.516	3.83	0.408	3.83	0.408	3.67	0.516	3.33	0.516	3.17	0.408	–	–
	10 mg	3.5	0.548	3.83	0.408	4.17	0.408	6.5	0.548	4.67	0.516	4.17	0.408	3.67	0.516	–	–
	20 mg	3.33	0.516	3.83	0.408	4.17	0.408	7.5	0.548	5.17	0.408	4.17	0.753	3.67	0.516	–	–
	p-value	0.827		0.761		0.293		<0.001		<0.001		0.036		–		–
Ami	5 mg	3.33	0.516	3.67	0.516	3.83	0.408	4.17	0.408	3.5	0.548	3.17	0.408	–	–	–	–
	10 mg	3.33	0.516	4.17	0.408	6.83	0.753	4.83	0.753	3.67	0.516	3.17	0.408	–	–	–	–
	20 mg	3.5	0.548	5.17	0.408	8.17	0.753	5.33	0.516	3.67	0.516	3.33	0.516	–	–	–	–
	p-value	0.821		<0.001		<0.001		0.011		0.821		0.761		–		–
Ros	2.5 mg	3.17	0.408	3.67	0.516	3.67	0.516	3.83	0.408	3.67	0.516	3.33	0.516	3.33	0.516	–	–
	5 mg	3.33	0.516	4.17	0.408	6.33	0.516	7.67	0.516	5.33	0.516	3.83	0.408	3.67	0.516	–	–
	10 mg	3.33	0.516	3.83	0.753	4.17	0.983	8.33	0.816	5.33	0.516	3.83	0.408	3.67	0.516	–	–
	p-value	0.791		0.338		<0.001		<0.001		<0.001		0.116		0.454		–

Significance of footnote “∗” is represents statitically significant at p < 0.05.