Table 4.
Evaluation of Analgesic activity - Maximum Possible Efficacy (MPE %) of the study drugs with Tail-Flick model of Pain.
| Time of testing | Mean Maximum Possible Efficacy (%) of the tested formulations in radiant heat tail-flick model in mice (n = 6) |
||||
|---|---|---|---|---|---|
| Tab Piroxicam |
Tab Diclofenac |
Tab Ibuprofen |
Inj Piroxicam |
Inj Diclofenac |
|
| Before expiry | 44.72 ± 8.24 | 57.56 ± 6.53 | 64.86 ± 4.52 | 58.54 ± 5.87 | 68.67 ± 9.02 |
| At expiry | 51.63 ± 5.30 | 52.41 ± 5.54 | 60.02 ± 5.26 | 55.59 ± 6.88 | 64.13 ± 9.24 |
| 6 months after expiry | 53.69 ± 8.46 | 55.52 ± 4.27 | 65.05 ± 6.94 | 62.76 ± 10.04 | 69.70 ± 8.95 |
| 12 months after expiry | 55.11 ± 14.07 | 58.75 ± 5.20 | 65.73 ± 6.16 | 57.43 ± 7.82 | 65.68 ± 6.67 |
| 18 months after expiry | 48.84 ± 9.05 | 51.34 ± 6.84 | 63.65 ± 5.47 | 56.10 ± 7.70 | 60.03 ± 9.58 |
| 2 years after expiry | 50.08 ± 3.18 | 53.98 ± 4.61 | 61.24 ± 4.44 | 59.38 ± 6.60 | 63.43 ± 3.74 |
| One-way ANOVA df (5,30) | F = 1.082 p = 0.38 | F-1.60 p = 0.18 | F = 1.03 p = 0.41 | F = 0.70 p = 0.62 | F = 1.18 p = 0.34 |
(P > 0.05 for all the drugs during the entire study period).