Table 3.
Predictors of early mortality in HLH patients.
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | |
| CNS involvement | 15.8 (3.7–66.8) | <0.001* | 13 (2–83) | 0.007* |
| Platelet <44 × 106/mm3 | 7.2 (1.8–28.9) | 0.006* | 8 (1.3–49) | 0.024* |
| PTT > 35 s (n = 72)a | 5.6 (1.4–22.6) | 0.015* | 2 (0.3–13.9) | 0.48 |
| Albumin <25 g/L | 1.8 (0.5–5.9) | 0.35 | ||
| Total bilirubin >1.8 mg/dL | 11 (2.2–54.2) | 0.003* | 4.7 (0.7–32.7) | 0.155 |
HLH, hemophagocytic lymphohistiocytosis; CNS, central nervous system; PTT, partial thromboplastin time; OR, odds ratio; CI, confidence interval. *p <0.05 was considered statistically significant. apatients without early mortality (n = 59), patients with early mortality (n = 13).